Stanford's Simone Manuel, taking a leave of absence from collegiate competition to train for the 2016 Rio Olympics, set a short course American record in the 100 free and swam the anchor on the U.S. women's 400 medley relay team that set a world record Friday at the Mutual of Omaha Duel in the Pool in Indianapolis.
Fellow Cardinal Lia Neal was second in the 100 free and Stanford grad Eugene Godsoe finished fifth in the 100 fly. The U.S. men also set an American record in the relay.
Team USA leads Team Europe, 74-48, after the first day of the event at the Indiana Nataorium.
Manuel bettered Natalie Coughlin's mark in the 100 free by rallying from behind and getting past Neal, 51.69-52.08.
"I think a lot of the people in the field were going to take it out fast, so I tried to stay patient and really bring it home at the end of the race," Manuel told USA Swimming.
The Americans were .02 seconds behind the Europeans when Manuel dove in to complete the relay. She went 51.23 over the final 100 meters, edging Ranomi Kromowidjojo (51.51) and touching at 3:45.20 to Europe's 3:45.46.
Courtney Bartholomew, Katie Meili and Kelsi Worrell set the pace early for the U.S., which surpassed its own record from 2011.
The men's medley relay of Matt Grevers, Kevin Cordes and Cal grads Tom Shields and Nathan Adrian set the American record with a 3:20.91. Grevers also swam to an American mark in the 100 back, going 49.25 to start the race.
The event continues Saturday.